Water Soluble Macromolecules.
Green tea contains various water soluble macromolecules. GTND (green tea non-dialysate) is one of these (molecular weight more than 12,000. GTND has anti-tumor function. GTND suppressed duodenal tumors in mice induced by ENNG（N-ethyl-N’-nitro-N-nitrosoguanidine. When 0.05 % GTND was administered to mice in the drinking water, the number of mice with tumors, the number of total tumors, the number of tumors per one mouse and the weight of tumor were suppressed compared with controls. The number of total tumors was suppressed significantly. No suppression was observed when the level of GTND was reduced by 0.005 %. Hetero-polysaccharides are other water soluble macromolecules of green tea that showed antiglycemic action.